In recent years, many researchers have discovered that the insoluble particles in liquid medicine will inevitably enter the human body through intravenous infusion or intravenous injection, which may cause acute reactions or potential dangers, and the harm is serious and long-lasting.

These hazards mainly include vascular embolism, infarction, hemorrhage, granuloma, pulmonary fibrosis, allergic reactions, cancer reactions, pyrogen reactions, phlebitis, thrombocytopenia, increased venous pressure, pulmonary hypertension, etc. The use of a precision filter infusion set can avoid these situations to a large extent. The following is the necessity of using a disposable precision filter infusion set.

At present, the medical liquid filter of the common infusion set in clinical use uses a cellulose filter membrane, which does not carry out precise pore grading. When using more than a certain amount, or after encountering acid and alkali, the fiber will fall off and produce a large number of insoluble particles, which will cause self-pollution. The liquid medicine filter of the ordinary infusion set mainly filters out particles with a diameter of 15 μm or more in the liquid medicine, and the filtration rate for particles below 15 μm is low.

The filter membrane selected for the precision filtration infusion set is a nuclear porous membrane with a double-layer filter medium, which has strong dirt holding capacity, regular and uniform filter holes, high filtration accuracy, and will not cause foreign matter to fall off. In addition, it has low drug adsorption and strict grading of the pore size. The appropriate pore size can be selected according to clinical needs: 5μm, 3μm, 2μm.

1. Dust particles, mainly smoke and dust pollution in the production and liquid preparation environment;

2. Glass fragments and fibers are mainly produced by cutting ampoules;

3. Cotton fiber, the filter medium falls off by itself;

4. Plastic particles, particles that are invisible to the naked eye in the infusion product;

5. Fat plugs, fat emulsions are not completely emulsified;

6. Rubber particles, rubber plugs, and puncture rubber plugs are produced;

7. Carbon particles are mainly produced during the drug production process;

8. Drug crystallization, caused by temperature and humidity changes, pH changes, and interactions between drugs;

9. The preparation of instruments and liquid medicine and other pollution-related to the infusion process.

The average diameter of capillaries in the human body is only 7μm-9μm, and the smallest is 4μm. If the fluid is infused frequently, particles with a diameter of more than 4μm in the drug solution will accumulate in the capillaries such as the heart, liver, lung, brain, kidney, muscle, and skin.

 Larger particles can directly cause capillary embolism, causing local insufficient blood supply, tissue hypoxia and leading to edema and inflammation. Smaller particles may be swallowed by macrophages, causing the macrophages to enlarge and form granulomas. These changes can occur in the whole body's tissues, especially the lungs. In addition, particles can directly cause exothermic reactions.

At present, in addition to bacterial contamination reaction and pyrogen reaction, in the infusion process, the particle contamination reaction caused by insoluble particles has also attracted more and more attention.

The use of a precision filter infusion set is an effective measure to reduce the infusion reaction because the liquid filter of the infusion set is the last way to filter out the particles in the liquid. Through experiments, it is found that the use of a disposable precision infusion device for infusion can greatly reduce the occurrence of infusion reactions.

BQ+ provides a complete selection of infusion sets with precision filters, which meets the ISO 80369-7 standard in the medical industry. If you are interested in this, you can learn about it by searching related products on our website.

As one of the world's leading manufacturers of medical products, BQ+ has more than 450 types of medical parts for you to choose from and also provides R&D customized services for customers with special requirements. We do our utmost to pay attention to the health of patients, have established a strict quality inspection system, and are committed to providing customers with safe and high-quality products. Our complete management team can provide customers with thoughtful one-stop service. If you want to buy our high-quality precision filter infusion set, please contact us immediately!